发明名称 |
MODULATION OF LMW-PTPASE EXPRESSION |
摘要 |
Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase. |
申请公布号 |
WO2006127913(A3) |
申请公布日期 |
2007.04.12 |
申请号 |
WO2006US20272 |
申请日期 |
2006.05.24 |
申请人 |
ISIS PHARMACEUTICALS, INC.;PANDEY, SANJAY, K.;MCKAY, ROBERT;BHANOT, SANJAY;YU, XING-XIAN |
发明人 |
PANDEY, SANJAY, K.;MCKAY, ROBERT;BHANOT, SANJAY;YU, XING-XIAN |
分类号 |
A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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