发明名称 |
LIPASES FOR PHARMACEUTICAL USE |
摘要 |
The pharmaceutical use of lipases related to a variant of the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 1, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have an improved efficacy in vivo, are stable against protease-degradation, and/or are stable in the presence of bile salts. |
申请公布号 |
WO2006136159(A3) |
申请公布日期 |
2007.04.12 |
申请号 |
WO2006DK00352 |
申请日期 |
2006.06.16 |
申请人 |
NOVOZYMES A/S;SOLVAY PHARMACEUTICALS GMBH;SVENDSEN, ALLAN;BORCH, KIM;GREGORY, PETER, COLIN |
发明人 |
SVENDSEN, ALLAN;BORCH, KIM;GREGORY, PETER, COLIN |
分类号 |
C12N9/20;A61K38/46;A61K38/54 |
主分类号 |
C12N9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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