COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING INFLAMMATORY DISORDERS

摘要

The present invention relates, generally, to methods and compositions for detecting or treating inflammatory disorders, such as multiple sclerosis, systemic lupus erythematosus or psoriasis. The present invention more particularly discloses the identification of human genes, which can be used for the diagnosis, prevention, and treatment of multiple sclerosis, systemic lupus erythematosus, psoriasis and related disorders, as well as for the screening of therapeutically active drugs. The invention further discloses specific polymorphisms, splice variants or alleles of the NRG1 gene that are related to multiple sclerosis, systemic lupus erythematosus and psoriasis, as well as diagnostic tools and kits based on these polymorphisms. The invention can be used in the diagnosis of or predisposition to, detection, prevention and/or treatment of multiple sclerosis, systemic lupus erythematosus, psoriasis and related disorders.