发明名称 SULPHONYLPYRROLE HYDROCHLORIDE SALTS AS HISTONE DEACETYLASESINHIBITORS
摘要 Compounds of formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors. In more detail, this invention refers to salts of a compound selected from (E)-(E)-N-hydroxy-3-(1-[4-(([2-(1H-indol-2yl)-ethyl]- methyl-amino)-methyl)-benzene sulfonyl]-1H-pyrrol-3-yl)-acrylamide, (E)-3-[1 - (4-dimetylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide, and (E)-N-hydroxy-3-[1-(5-pyridin-2-yl-thiophene-2-sulfonyl)-1H-pyrrol-3-yl] - acrylamide with hydrochloric acid, their hydrates and to crystalline forms o f these salts and hydrates.
申请公布号 CA2622670(A1) 申请公布日期 2007.04.12
申请号 CA20062622670 申请日期 2006.09.08
申请人 NYCOMED GMBH 发明人 BECKERS, THOMAS;MUELLER, MATTHIAS;BAER, THOMAS;FETH, MARTIN;HUMMEL, ROLF-PETER;MAIER, THOMAS
分类号 C07D207/48;A61K31/40 主分类号 C07D207/48
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