发明名称 |
TUMOR SELECTIVE AND BIODEGRADABLE POLYPHOSPHAZENE-PLATINUM(II) CONJUGATE ANTITUMOR AGENT, AND PREPARATION METHOD THEREOF |
摘要 |
Disclosed are a new class of a polyphosphazene-platinum(II) conjugate antitumor agent having high tumor tissue selectivity due to its enhanced permeability and retention effect to tumor tissues, and a preparation method thereof: wherein x represents the number of the ethylene oxide repeating unit and is 7, 12 or 16; y is 0, 1 or 2; z represents molar content of polyethylene glycol in the range of 0.5-1.5; n represents degree of polymerization of polyphosphazene in the range of 30-100; and A-A represents a diamine. |
申请公布号 |
EP1618117(A4) |
申请公布日期 |
2007.04.11 |
申请号 |
EP20030781060 |
申请日期 |
2003.12.30 |
申请人 |
BOARD OF TRUSTEES, EWHA WOMANS UNIVERSITY |
发明人 |
SOHN, YOUN SOO;JUN, YONG JOO;KIM, JOO IK |
分类号 |
C07F19/00;A61K31/80 |
主分类号 |
C07F19/00 |
代理机构 |
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代理人 |
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地址 |
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