发明名称 |
Novel photolabile protective groups for improved processes to prepare oligonucleotide arrays |
摘要 |
<p>The present invention discloses novel and improved nucleosidic and nucleotidic compounds that are useful in the light-directed synthesis of oligonucleotides, as well as, methods and reagents for their preparation. These compounds are characterized by novel photolabile protective groups that are attached to either the 5′- or the 3′-hydroxyl group of a nucleoside moiety. The photolabile protective group is comprised of a 2-(2-nitrophenyl)-ethyoxycarbonyl skeleton with at least one substituent on the aromatic ring that is either an aryl, an aroyl, a heteroaryl or an alkoxycarbonyl group. The present invention includes the use of the aforementioned compounds in light-directed oligonucleotide synthesis, the respective assembly of nucleic acid microarrays and their application.</p> |
申请公布号 |
GB2414237(B) |
申请公布日期 |
2007.04.11 |
申请号 |
GB20050017834 |
申请日期 |
2004.02.19 |
申请人 |
NIGU CHEMIE GMBH;NIMBLEGEN SYSTEMS GMBH |
发明人 |
SIGRID BUHLER;MARKUS OTT;WOLFGANG PFLEIDERER |
分类号 |
C07H13/12;B01J19/00;C07H19/00;C07H19/06;C07H19/16;C07H21/00 |
主分类号 |
C07H13/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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