发明名称 |
Matrix metalloproteinase inhibitors and uses thereof |
摘要 |
The present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in treatment of diseases associated with MMPs.
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申请公布号 |
EP1772452(A2) |
申请公布日期 |
2007.04.11 |
申请号 |
EP20060076915 |
申请日期 |
2001.02.15 |
申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
DECICCO, CARL P.;NELSON, DAVID J.;BARRETT, JOHN A.;CARPENTER, ALAN P.;DURAN, JAMES J.;RAJOPADHYE, MILIND |
分类号 |
C07D413/12;A61K31/395;A61K31/4427;A61K31/661;A61K49/00;A61K49/14;A61K51/04;A61K51/08;A61P29/00;A61P35/00;C07D207/26;C07D213/82;C07D267/00;C07D401/12;C07D401/14;C07F9/09;C07F9/6527 |
主分类号 |
C07D413/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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