发明名称 |
METHODS FOR THE PURIFICATION OF STABLE RADIOIODINE CONJUGATES |
摘要 |
The present invention is directed toward a method for preparing and purifying a conjugate of a radioiodinated aminopolycarboxylate-appended peptide and a targeting agent. The method involves (A) providing a solution comp rising (i) unbound radioiodine (ii) a radioiodinated aminopolycarboxylate-appended peptide that is not conjugated to a targeting agent (iii) and a radioiodinated aminopolycarboxylate-appended peptide that is conjugated to the targeting agent; (B) contacting the solution with an anion-exchange resin; and (C) passing the anion-exchange resin and solution together through a filter capable of trapping anion-exchange resin particles. |
申请公布号 |
EP1592476(B1) |
申请公布日期 |
2007.04.11 |
申请号 |
EP20040708243 |
申请日期 |
2004.02.04 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOVINDAN, SERENGULAM, V. |
分类号 |
G01N33/534;A61K38/00;A61K51/00;A61K51/04;A61K51/08;A61K51/10;A61M36/00;A61N;A61N1/00;C07H3/04;C07K1/107;C07K1/14;G01N33/543 |
主分类号 |
G01N33/534 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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