| 发明名称 |
Cycloalkyl inhibitors of potassium channel function |
| 摘要 |
Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K<SUB>v</SUB>1 subfamily of voltage gated K<SUP>+</SUP> channels, especially inhibitors K<SUB>v</SUB>1.5 which has been linked to the ultra-rapidly activating delayed rectifier K<SUP>+</SUP> current I<SUB>Kur</SUB>), methods of using such compounds in the prevention and treatment of arrhythmia and I<SUB>Kur</SUB>-associated conditions, and pharmaceutical compositions containing such compounds.
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| 申请公布号 |
US7202253(B2) |
申请公布日期 |
2007.04.10 |
| 申请号 |
US20040997734 |
申请日期 |
2004.11.24 |
| 申请人 |
ICAGEN, INC. |
发明人 |
LLOYD JOHN;JEON YOON T.;FINLAY HEATHER;YAN LIN;GROSS MICHAEL F.;BEAUDOIN SERGE |
| 分类号 |
A61K31/4709;A61K;A61K31/519;A61K45/06;C07C233/58;C07C233/59;C07C233/60;C07C233/65;C07C235/06;C07C235/34;C07C235/46;C07C235/60;C07C279/16;C07C279/24;C07C279/28;C07C307/02;C07C307/04;C07C307/08;C07C307/10;C07C311/16;C07C311/29;C07C311/55;C07C311/59;C07C311/64;C07C323/62;C07D213/40;C07D213/69;C07D213/82;C07D217/22;C07D233/48;C07D233/54;C07D233/76;C07D235/10;C07D235/14;C07D239/42;C07D239/84;C07D239/94;C07D239/95;C07D241/06;C07D249/04;C07D251/44;C07D251/46;C07D261/08;C07D261/14;C07D271/06;C07D295/13;C07D295/185;C07D295/215;C07D295/26;C07D307/68;C07D309/04;C07D309/08;C07D333/20;C07D333/28;C07D333/38;C07D333/58;C07D333/62;C07D409/12;C07D413/12;C07D471/04;C07D471/06;C07D487/04;C07D521/00 |
主分类号 |
A61K31/4709 |
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