| 摘要 |
<p>This invention is directed generally to triazolopyridine compounds that generallyinhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridineinclude compounds generally corresponding in structure to the following formula(I): Wherein R1, R2, R3, R4, and R5are as defined in this specification. This invention also is directed tocompositions of such triazolopyridines (particularly pharmaceutical compositions),intermediates for the syntheses of such triazolopyridines, methods for makingsuch triazolopyridines, and methods for treating (including preventing) conditions(typically pathological conditions) associated with p38 kinase activity,TNF activity, and/or cyclooxygenase-2 activity.</p> |
