发明名称 |
Identification of kinase inhibitors |
摘要 |
The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using a covalent tethering approach to identify inhibitors preferentially targeting the inactive conformation.
|
申请公布号 |
US7202033(B2) |
申请公布日期 |
2007.04.10 |
申请号 |
US20030394322 |
申请日期 |
2003.03.20 |
申请人 |
SUNESIS PHARMACEUTICALS, INC. |
发明人 |
PRESCOTT JOHN C.;BRAISTED ANDREW |
分类号 |
C12Q1/68;G01N33/566;C12N15/09;C12Q1/48;C40B30/04;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|