发明名称 |
Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 |
摘要 |
Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
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申请公布号 |
US7202256(B2) |
申请公布日期 |
2007.04.10 |
申请号 |
US20050103779 |
申请日期 |
2005.04.12 |
申请人 |
WYETH |
发明人 |
GU JIANXIN;RUPPEN MARK E.;RAVEENDRANATH PANOLIL;CHEW WARREN;SHAW CHIA-CHENG |
分类号 |
C07D498/18;A61K31/435;A61K31/436;A61K31/4745;C07D281/18;C07D491/04;C07D498/08;C07D498/22;C07F7/18 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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