| 发明名称 |
THIMEROSAL-FREE PRESERVATIVES FOR VACCINES |
| 摘要 |
Novel combination of preservatives (methyl and propyl parabens, benzyl alcohol, and 2-phenoxyethanol) were found to pass antimicrobial testing according to USP, BP, and EP. The new preservatives we re put into vaccines using L-histidine as a buffer to keep p11 at 7.0. HPLC methods were developed to analyze these preservatives and their degradation products.
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| 申请公布号 |
CA2278684(C) |
申请公布日期 |
2007.04.10 |
| 申请号 |
CA19982278684 |
申请日期 |
1998.02.03 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
MANCINELLI, RALPH J.;NG, ASSUNTA S.;HENNESSEY, JOHN P. |
| 分类号 |
A61K9/08;A61K39/00;A61K9/00;A61K39/02;A61K39/12;A61K47/10;A61K47/12;A61K47/14;A61K47/18 |
主分类号 |
A61K9/08 |
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