CONTRACEPTION USING COMPETITIVE PROGESTERONE ANTAGONISTS, AND NOVEL COMPOUNDS USEFUL THEREFOR

摘要

Competitive arogesterone antagonists, including two novel steroids, viz., 11.beta.,19-[4-(cyanophenyl)-o-phenylene]- 17.beta.-hydroxy-17.alpha.-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11.beta.,19-[4-(3-pyridinyl)-o-phenylene]-17.beta.-hydroxy-17.alpha. -(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one, inhibit formation of endometrial glands at below their ovulation inhibiting dose and the abortive dose, and thus achieve oral contraception in females without adversely affecting the menstrual cycle and without risk of.aborting a previous implanted fertilized egg or a fetus.