发明名称 |
OVR110 ANTIBODY COMPOSITIONS AND METHODS OF USE |
摘要 |
The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti- Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti- Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti- Ovr110 antibodies. The invention encompasses a method of producing the anti- Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti- Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti- Ovr110 antibody to the mammal. |
申请公布号 |
WO2006074418(A3) |
申请公布日期 |
2007.04.05 |
申请号 |
WO2006US00575 |
申请日期 |
2006.01.09 |
申请人 |
DIADEXUS, INC.;PAPKOFF, JACKIE;SHROYER, KENNETH, R. |
发明人 |
PAPKOFF, JACKIE;SHROYER, KENNETH, R. |
分类号 |
C07K16/00;A61K39/395 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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