CHLORO-SUBSTITUTED GUANIDINES

摘要

The present invention relates to compounds of formula wherein R¹ is hydrogen or halogen; R² is lower alkyl; R³ is hydrogen, lower alkyl, -(CH₂)_n-cycloalkyl, -(CH₂)_n-phenyl optionally substituted by halogen, or is lower alkyl substituted by halogen, or is -(CH₂)_n-heterocyclyl, -(CH₂)_nN-di-lower alkyl, -(CH₂)_nNHC(O)-lower alkyl, adamantly or -(CH₂)_n-O-lower alkyl; n is 0, 1, 2 or 3; and pharmaceutically acceptable acid addition salts and tautomers thereof. It has been found that the compounds of formula I have a good activity on the 5-HT_5A receptor. Therefore, the invention provides the use of a compound of formula I or a pharmaceutically acceptable salt thereof for the treatment of diseases, related to this 15 receptor.