发明名称 |
IL-17A AND IL-17F ANTAGONISTS AND METHODS OF USING THE SAME |
摘要 |
<p>The present invention relates antagonists of IL-17A and IL-17F. The antagonists of the invention are based on IL-17RC alone or on both IL-17RC and IL-17RA ("IL-17RC/IL-17RA"). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL-17RA is a receptor for IL-17A and IL-17RC is a common receptor for both IL-17A and IL-17F. The present invention includes soluble IL-17A and IL-17F antagonists, as well as methods for using the same.</p> |
申请公布号 |
CA2621623(A1) |
申请公布日期 |
2007.04.05 |
申请号 |
CA20062621623 |
申请日期 |
2006.09.28 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
LEVIN, STEVEN D.;RIXON, MARK W.;LEWIS, KATHERINE E.;GAO, ZEREN;BILLSBOROUGH, JANINE;TAFT, DAVID W. |
分类号 |
C07K14/715;A61K38/17;A61K38/20;A61K39/395;A61P29/00;C07K14/52;C07K16/28;C12P21/08 |
主分类号 |
C07K14/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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