摘要 |
The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA). |
申请人 |
POSTECH FOUNDATION;POSTECH ACADEMY-INDUSTRY FOUNDATION;KIM, YOUN-DONG;LEE, BYOUNG-DAE;KIM, YOE-KYUNG;BAE, YOE-SIK;LEE, TAE-HOON;SUH, PANN-GHILL;RYU, SUNG-HO |
发明人 |
KIM, YOUN-DONG;LEE, BYOUNG-DAE;KIM, YOE-KYUNG;BAE, YOE-SIK;LEE, TAE-HOON;SUH, PANN-GHILL;RYU, SUNG-HO |