PROCESSES FOR PREPARATION OF AMORPHOUS CEFEPIME ACID ADDITION SALTS

摘要

The present invention provides processes for the preparation amorphous form of Cefepime acid addition salt in high purity which exhibits very good thermal stability on storage. The processes are simple and cost-effective. The selective solvent precipitation method comprises of: (a) dissolving cefepime acid addition salt or solvates thereof in a polar solvent, (b) addition of less polar solvent to the solution obtained in step (a) to precipitate out cefepime acid addition salt followed by isolation of solid by filtration and drying or alternatively, (a) dissolving cefepime acid addition salt or solvates thereof in a polar solvent, (b) addition of the solution obtained in step (a) to less polar solvent to precipitate out cefepime acid addition salt followed by isolation of solid by filtration and drying. The further method involves spray drying of solution of cefepime acid addition salt or solvates thereof prepared in a polar solvent.