TREATMENT OF TNF ANTAGONIST-RESISTANT INFLAMMATORY DISORDERS AND RELATED METHODS

摘要

In certain embodiments, the invention provides methods of treatment in which a VLA-I antagonist is administered to a patient who suffers from one or more inflammatory disorders, wherein: (1) the patient does not respond adequately to, or is unlikely to respond adequately to, TNFa antagonist therapy; or (2) the patient evidences tachyphylaxis and/or refractory effects during TNFa antagonist therapy; or (3) the VLA-I antagonist is administered as an adjuvant to TNFa antagonist monotherapy; and (4) wherein administration of the VLA-I antagonist is effective in treating the patient's inflammatory disorder(s).