发明名称 |
OXYGENATED POLYMERIZED HEMOGLOBIN SOLUTIONS AND THEIR USES FOR TISSUE VISUALIZATION |
摘要 |
An oxygenated Hemoglobin (Hb) solution includes from about 10 g to about 250 g of polymerized Hb per liter of solution. About 80% by weight, or greater, of the polymerized Hb of the oxygenated hemoglobin solution is oxyhemoglobin. About 18% by weight, or less, of the polymerized Hb has a molecular weight of over 500,000 Daltons. About 5% by weight, or less, of the polymerized Hb has a molecular weight equal to or less than 65,000 Daltons. A P<SUB>50</SUB> of the polymerized Hb is in a range of between about 34 and about 46 mm Hg. An endotoxin content of the oxygenated Hb solution is less than about 0.05 endotoxin units per mL. A method of visualizing a tissue or organ of a subject includes the steps of administering to the subject an oxygenated hemoglobin solution as described above, and imaging the tissue, blood vessel or organ with an imaging system. A method of producing an oxygenated Hb solution includes the step of oxygenating a Hb solution that includes polymerized Hb as described above to thereby cause about 80% by weight, or greater, of the polymerized Hb to become oxyhemoglobin. |
申请公布号 |
WO2006108047(A3) |
申请公布日期 |
2007.04.05 |
申请号 |
WO2006US12676 |
申请日期 |
2006.04.05 |
申请人 |
BIOPURE CORPORATION;RAUSCH, CARL, W.;LACCETTI, ANTHONY, J.;BAQAI, JAVED |
发明人 |
RAUSCH, CARL, W.;LACCETTI, ANTHONY, J.;BAQAI, JAVED |
分类号 |
A61K49/14;C07K14/805 |
主分类号 |
A61K49/14 |
代理机构 |
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