Use of 11-(4-piperidilydene)-5H-benzo[5,6]cyclohepta[1,2- b]pyridine compound as a farnesyl protein transferase inhibitor for the manufacture of a medicament for the treatment of proliferative disease

摘要

Disclosed is the use of lonafarnib of formula (I) as a farnesyl protein transferase inhibitor for the manufacture of a medicament for use concurrently or sequentially with an antineoplastic agent, which is preferably paclitaxel, and/or radiation therapy for the treatment of proliferative disease such as lung cancer, pancreatic cancer, colon cancer, myeloid leukaemia, melanoma, glioma, thyroid follicular cancer, bladder carcinoma, myelodysplastic syndrome, breast cancer or prostate cancer.