WRINKLING PREVENTION OR MITIGATION WITH ADAM INHIBITOR

摘要

Wrinkles are more effectively prevented or mitigated. An ADAM inhibitor comprising a benzohydroxamic acid represented by the following general formula (I) or a salt thereof is applied to the skin. [Chemical formula 1] (I) (In the formula, R<SUB>1</SUB>'s each independently is C<SUB>1-18</SUB> alkyl, C<SUB>3-8</SUB> cycloalkyl, halogeno, hydroxy, C<SUB>1-18</SUB> alkoxy, benzyloxy, amino, or acylamino; R<SUB>2</SUB> is hydrogen, methyl, or phenyl; and n is an integer of 0-3.)