发明名称 |
NOTCH mutations leading to increased receptor signaling |
摘要 |
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
|
申请公布号 |
US2007077245(A1) |
申请公布日期 |
2007.04.05 |
申请号 |
US20050194913 |
申请日期 |
2005.08.02 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
ASTER JON C.;BLACKLOW STEPHEN C.;LOOK A. T.;FERRANDO ADOLFO A.;WENG ANDREW P. |
分类号 |
G01N33/574;A61K39/395;C07H21/04;C07K14/705;C12P21/06 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|