发明名称 |
THERMOREVERSIBLE IMMUNO-ADJUVANT EMULSION |
摘要 |
The invention relates to an oil-in-water adjuvant emulsion including at least squalene, an aqueous solvent, a nonionic surfactant which is polyoxyethylene alkyl ether and a thermoreversible hydrophobic nonionic surfactant, in which adjuvant the size of 90 % of the oil droplet volume distribution is less than 200 nm. The invention also relates to a method of preparing an immunogenic composition, wherein at least one vaccine antigen is mixed with an oil-in-water emulsion. The invention is characterised in that the oil-in-water emulsion is obtained via a temperature-variation phase inversion method. |
申请公布号 |
WO2007006939(A3) |
申请公布日期 |
2007.04.05 |
申请号 |
WO2006FR01635 |
申请日期 |
2006.07.07 |
申请人 |
SANOFI PASTEUR |
发明人 |
KLUCKER, MARIE-FRANCOISE;DALENCON, FRANCOIS;PROBECK-QUELLEC, PATRICIA |
分类号 |
A61K39/39;A61K9/107;A61K39/145 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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