摘要 |
The present invention relates to a method of treating disorders of the nervous system and more particularly disorders associated with a gliotic response and/or an inflammatory response within the central nervous system and to therapeutic agents useful for same. More particularly, the present invention involves a method of preventing or reducing the amount of Eph receptor-mediated gliosis and/or glial scarring and/or inflammation and/or Eph receptor-mediated inhibition of axonal growth which occurs during and/or after disease or injury to the nervous system. The present invention also facilitates the identification of therapeutic agents which modulate Eph receptor-mediated signaling. The method and therapeutic agents of the present invention are useful for treating a range of nervous system diseases, conditions and injuries including, inter alia, paralysis induced by physiological-, pathological- or trauma-induced injury to the brain or spinal cord.
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申请人 |
THE UNIVERSITY OF QUEENSLAND;THE UNIVERSITY OF MELBOURNE;BARTLETT, PERRY, F.;GALEA, MARY, P.;GOLDSHMIT, YONA;TURNLEY, ANN, M.;BOYD, ANDREW, W. |
发明人 |
BARTLETT, PERRY, F.;GALEA, MARY, P.;GOLDSHMIT, YONA;TURNLEY, ANN, M.;BOYD, ANDREW, W. |