| 摘要 |
A heart stimulation device that markedly increases the coronary rate instantaneously and durably, causes dilatation of the walls to regress and opposes thromboses and arrhythmia. The device causes genetic involution of pathological processes by affecting the mechanosensitivity of specific genetic expressions or by addition of partial autologous cell dedifferentiation, obtained by original genetic manipulation which induces physiologic and anatomical regeneration. Processes for preparing cells which can be reimplanted prophylactically or therapeutically, wherein a nucleus of a differentiated cell is transported in an oocyte from a homologous or heterologous mammal or human, so as to induce stages of mitosis in the transferred nucleus, wherein this nucleus in mitosis is then removed from the oocyte before its cell division and then this partially dedifferentiated nucleus is introduced into a differentiated receiving cell. Also provided are physiological auto-contractile living arterial stents (e.g., coronary stents) and grafting of dedifferentiated myocardial cells.
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