摘要 |
<p>The invention discloses compounds of formula (I); wherein: R is a carboxylic acid or a derivative thereof; R<SUP>1</SUP> is alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, halo or trihalomethyl; R<SUP>2</SUP> is aryl, heteroaryl, arylalkyl or heteroarylalkyl; R<SUP>3</SUP> is H or F; and L is a linking group comprising a chain of from 2 to 8 atoms linking R and the carbonyl group (A); and pharmaceutically acceptable derivatives thereof, useful for treating disorders mediated by peroxisome-proliferator-activated receptor (PPAR) subtype d (PPARd). The compounds of the invention are therefore useful in the treatment of metabolic syndrome, obesity, type-II diabetes, dyslipidemia, wound healing, inflammation, neurodegenerative disorders and multiple sclerosis.</p> |
申请人 |
INPHARMATICA LIMITED;AYSCOUGH, ANDREW;OWEN, DAVID, RODNEY;MEO, PAUL;PEARSON, DAVID, JAMES;WALKER, YVONNE;BOYCE, RICHARD, JUSTIN;ZUCCOTTO, FABIO |
发明人 |
AYSCOUGH, ANDREW;OWEN, DAVID, RODNEY;MEO, PAUL;PEARSON, DAVID, JAMES;WALKER, YVONNE;BOYCE, RICHARD, JUSTIN;ZUCCOTTO, FABIO |