| 摘要 |
<p>The invention relates to methods of making antibodies, either monoclonal or polyclonal, which have dual binding specificity for a first antigenic epitiope which is a lipid epitope and a second antigenic epitope provided by an amino acid sequence of a protein, peptide or polypeptide. Monoclonal antibodies thus made include monoclonal antibodies that are broadly neutralizing to HIV-1 or other envelope viruses wherein the monoclonal antibody has subsites that simultaneously recognize protein and lipid epitopes from the virus.</p> |
