发明名称 |
Nucleic acid sequencing by FRET monitoring of molecular deconstruction |
摘要 |
The disclosed methods, apparatus and compositions are of use for nucleic acid sequencing. More particularly, the methods and apparatus concern sequencing single molecules of single stranded DNA or RNA by exposing the molecule to exonuclease activity, removing free nucleotides one at a time from one end of the nucleic acid, and identifying the released nucleotides by Raman spectroscopy or FRET. |
申请公布号 |
EP1770173(A2) |
申请公布日期 |
2007.04.04 |
申请号 |
EP20060021636 |
申请日期 |
2002.08.30 |
申请人 |
INTEL CORPORATION |
发明人 |
RAO, VALLURI;NEUBAUER, GABI;KIRCH, STEVEN;YAMAKAWA, MINEO;BERLIN, ANDREW |
分类号 |
C12Q1/68;G01N21/65;B01J19/00;B01L3/00;C12M1/00;C12M1/34;C12N15/00;C12Q1/44;G01N33/53;G01N33/543;G01N37/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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