发明名称 |
LIQUID DEPOT FORMULATIONS |
摘要 |
<p>The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.</p> |
申请公布号 |
EP1768650(A1) |
申请公布日期 |
2007.04.04 |
申请号 |
EP20050749850 |
申请日期 |
2005.06.06 |
申请人 |
CAMURUS AB;GODDARD, CHRISTOPHER |
发明人 |
THURESSON, KRISTER;TIBERG, FREDRIK;JOHANSSON, MARKUS;HARWIGSSON, IAN;JOABSSON, FREDRIK;JOHNSSON, MARKUS |
分类号 |
A61K9/10;A61K8/04;A61K8/37;A61K8/55;A61K8/67;A61K8/92;A61K9/00;A61K9/06;A61K9/12;A61K9/127;A61K9/70;A61Q11/00;A61Q19/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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