Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2

摘要

Disclosed is a composition comprising an effective amount of a curcumiriold species and an effective amount of andrographolide, wherein the ratio of the curcuminoid species and andrographolide is from 1:10 to 10:1, said composition being administered to an animal, has a synergistic effect on specific inhibition of inducible (COX-2) activity and has minimal effect on COX-1 activity. Also disclosed is the use of a composition comprising an effective amount of a circuminoid species and an effective amount of andrographolide in the manufacture of a medicament for the treatment of inflammation, arthritis, acne rosacea or psoriasis.