PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TISSUE DAMAGE OWING TO AN ARTERIAL IRRIGATION DEFECT

摘要

THIS INVENTION RELATES TO HUMAN MEDICINE, AND PARTICULARLY WITH A PHARMACEUTICAL COMBINATION MADE UP WITH EPIDERMAL GROWTH FACTOR (EGF) ADN A GROWTH HORMONE SECRETAGOGUE HEXAPEPTIDE (GHRP); BEING USEFUL TO PREVENT TISSUE DAMAGES DUE TO BLOOD FLOW SUPPRESSION AS TO ENHANCE TISSUE REPAIR FOLLWOING ISCHAEMIC DAMAGES. THE AFOREMENTIONED COMBINATION MAY BE APPLIED AS A SINGLE PHARMACEUTICAL COMPOSITION. ALTERNATIVELY, AN INDIVIDUAL MAY ALSO RECEIVE BOTH EGF AND GHRP IN A SEPARATE MANNER BUT WITHIN A SINGLE THERAPEUTIC REGIME TO ENHANCE CELLULAR SURVIVAL WHEN ORGANS ARE SUBJECTED TO BLOOD FLOW DEPRIVATION FOR A CRITICAL PERIOD OF TIME. THIS COMBINATION ATTENUATES REACTIVE OXYGEN SPECIES (ROS) FORMATION AND ITS ASSOCIATED CYTOTOXICITY. IT IS SUEFUL TO PROMOTE CELLULAR SURVIVAL WHEN TISSUES OR ORGANS ARE EXPOSED TO PROLONGED ISCHAEMIC PERIODS. THE COMBINATION MAY BE USED AS A PROPHYLACTIC AGENT IN THOSE SUBJECTS PRONE TO MULTIPLE ORGAN FAILURE (MOF) SUCH AS BURN VICTIMS, MULTIPLE TRAUMA PATIENTS, HYPOXIC NEONATES, ACUTE RESPIRAORY DISTRESS SYNDROME, AND NECROTIZING ENTEROCOLITIS PATIENTS.