| 摘要 |
Described are flaviviruses including one or more hinge region mutations that reduce viscerotropism of the flaviviruses. These flaviviruses can be, for example, yellow fever virus (e.g., a yellow fever virus vaccine strain); a viscerotropic flavivirus selected from the group consisting of Dengue virus, West Nile virus, Wesselsbron virus, Kyasanur Forest Disease virus, and Omsk Hemorrhagic fever virus; or a chimeric flavivirus. In one example of a chimeric flavivirus, the chimera includes the capsid and non-structural proteins of a first flavivirus virus (e.g., a yellow fever virus) and the pre-membrane and envelope proteins of a second flavivirus (e.g., a Japanese encephalitis virus or a Dengue virus (e.g., Dengue virus 1, 2, 3, or 4) ) including an envelope protein mutation that decreases viscerotropism of the chimeric flavivirus. |
