Pyrazolopyridines as antagonists of transforming growth factor beta (TGFbeta) type 1 receptors and methods of making and using the same

摘要

Disclosed herein are pyrazolopyridine compounds of formula (I), wherein: X1, X2, X3 and X4 are independently CRx or N, provided that only two of X1, X2, X3 and X4 can be N simultaneously; Y1 and Y2 are independently CRy or N, provided that at least one of Y1 and Y2 must be N; and the other variables are as defined in the specification. These compounds are used for the manufacture of medicaments for inhibiting the Transforming Growth Factor beta (TGFbeta) signalling pathway in a subject.These compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.