Pharmaceutical compositions comprising 3-aza-bicyclo[3.2.1]octane derivatives for the treatment of diseases related to neurotrophines

摘要

Pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II) and (III) acting as agonists of human neurotrophines and pharmaceutically acceptable excipient and/or diluent is disclosed, wherein the variables shown in these formulae are as defined in the specification. Therefore, such compounds of formula (I), (II) and (III) are useful for treatment of diseases in which the neurotrophine functions are involved in defect, particularly of Nerve Growth Factor (NGF), such as neurodegenerative diseases of central nervous system (CNS), acquired immundeficiency due to a reduced NGF biodisponibility, or morbous conditions in which the stimulus of neoangiogenesis process is convenient.