INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS

摘要

The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, V, X, and Y are independently selected from the group consisting of CR4 and N; Z is from the group consisting of CR³ and N; W and W' are independently selected from the group consisting of CH₂, CR ⁷R⁸, NR⁹, O, N(O), S(O)_q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.