ANTIBODIES TO COMPLEMENTARY PEPTIDES OF THROMBIN OR PORTIONS THEREOF
摘要
<p>Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subj ect in need of such treatment are disclosed.</p>
申请公布号
WO2007035406(A1)
申请公布日期
2007.03.29
申请号
WO2006US35829
申请日期
2006.09.14
申请人
THE BOARD REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;ORTHOLOGIC CORP.;FULLER, GERALD, M.;CARNEY, DARRELL, H.;BERGMANN, JOHN, S.
发明人
FULLER, GERALD, M.;CARNEY, DARRELL, H.;BERGMANN, JOHN, S.