| 摘要 |
The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of TRPSl mRNA and/or protein in hair follicle cells of a subject. The present invention also provides for methods of promoting hair growth, comprising increasing the level of TRPSl mRNA and/or protein in hair follicle cells of a subject. The level of TRPSl may be decreased or increased either directly, for example by introducing, into a hair follicle cell, a TRPSl mRNA or protein. Alternatively, the level of TRPSl may be decreased or increased indirectly, by providing an agent that results in decreased or increased expression of an endogenous TRPSl gene. The invention also provides for transgenic animals with aberrancies in TRPS 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase TRPSl expression. |
