RATIOMETRIC MULTICOLOUR FLUORESCENCE CORRELATION SCREENING; AGENTS FOR USE THEREWITH AND METHODS OF PRODUCTION THEREOF

摘要

The present invention provides ratio-metrically labelled lipid carrier particles having at least two fluorescent signals and mixtures thereof, each carrier particle having incorporated in or on its shell surface at least one target receptor. The invention also includes a method of screening the particles with a range of probe ligands in sorting or binding assays and in a ratio-metric multicolour fluorescence correlation spectroscopy screen. The carrier particles are especially useful for carrying membrane proteins as the target receptors.