| 发明名称 |
METALLO-.BETA.-LACTAMASE INHIBITOR |
| 摘要 |
Disclosed is a metallo-.beta.-lactamase inhibitor which can inactivate a .beta.-lactam antibiotic and recover the anti-bacterial activity of the .bet a.- lactam antibiotic. A maleic acid derivative having a structure of the genera l formula (I) has an inhibitory activity against metallo-.beta.-lactamase. The use of the compound (I) in combination with a .beta.-lactam antibiotic enabl es to recover the anti-bacterial activity of the .beta.-lactam antibiotic again st a bacterium capable of producing mettalo-.beta.-lactamase. |
| 申请公布号 |
CA2620675(A1) |
申请公布日期 |
2007.03.29 |
| 申请号 |
CA20062620675 |
申请日期 |
2006.09.22 |
| 申请人 |
MEIJI SEIKA KAISHA, LIMITED |
发明人 |
KUDO, TOSHIAKI;MORINAKA, AKIHIRO;HIRAIWA, YUKIKO;ABE, TAKAO;CHIKAUCHI, KEN;KURAZONO, MIZUYO |
| 分类号 |
A61K31/194;A61K31/225;A61K31/341;A61K31/351;A61K31/4164;A61K31/4406;A61K31/445;A61K31/4453;A61K31/495;A61K31/5375;A61K45/00;A61P31/04;A61P43/00;C07C57/145;C07C57/26;C07C57/42;C07C57/48;C07C57/50;C07C59/42;C07C59/46;C07C59/52;C07C59/60;C07C59/68;C07C65/00;C07C69/60;C07C69/618;C07C69/675;C07C69/736;C07C217/22;C07C233/65;C07C235/06;C07C237/06;C07C279/08;C07C323/54 |
主分类号 |
A61K31/194 |
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