| 摘要 |
The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders. |
| 申请人 |
MERCK SHARP & DOHME LIMITED;CARLING, WILLIAM ROBERT;ELLIOTT, JASON, MATTHEW;MEZZOGORI, ELENA;RUSSELL, MICHAEL, GEOFFREY, NEIL;WILLIAMS, BRIAN, JOHN |
发明人 |
CARLING, WILLIAM ROBERT;ELLIOTT, JASON, MATTHEW;MEZZOGORI, ELENA;RUSSELL, MICHAEL, GEOFFREY, NEIL;WILLIAMS, BRIAN, JOHN |
