发明名称 METHODS AND MATERIALS FOR IDENTIFYING THE ORIGIN OF A CARCINOMA OF UNKNOWN PRIMARY ORIGIN
摘要 The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
申请公布号 WO2007035676(A2) 申请公布日期 2007.03.29
申请号 WO2006US36355 申请日期 2006.09.19
申请人 VERIDEX., LLC;WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN 发明人 WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN
分类号 C12Q1/68;C12M1/34;G01N33/574;G06F19/00 主分类号 C12Q1/68
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