METHODS AND MATERIALS FOR IDENTIFYING THE ORIGIN OF A CARCINOMA OF UNKNOWN PRIMARY ORIGIN
摘要
The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.
申请公布号
WO2007035676(A2)
申请公布日期
2007.03.29
申请号
WO2006US36355
申请日期
2006.09.19
申请人
VERIDEX., LLC;WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN
发明人
WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN