CORNEAL NEURITOGENESIS PROMOTER CONTAINING PACAP AND ITS DERIVATIVE.

摘要

It is intended to provide a corneal neuritogenesis promoter containing PACAP, a PACAP derivative or a pharmaceutically acceptable salt thereof, in particular, a corneal neuritogenesis promoter aiming at improving corneal perception, treating dry eye and treating corneal epithelial injury due to an effect of promoting corneal neuritogenesis. This corneal neuritogenesis promoter is useful as a drug for ameliorating reduction in corneal perception following corneal surgeries such as laser keratonomy (LASIK) and corneal grafting or cataract surgery, reduction in corneal perception accompanying corneal neurodegeneration and dry eye symptom and corneal epithelial injury accompanying such reduction in corneal perception. Moreover, it is useful as a drug for ameliorating dry eye symptom, reduction in corneal perception and corneal epithelial injury in patients with dry eye, and a drug for ameliorating corneal epithelial injury and dry eye symptom and reduction in corneal perception accompanying therewith.