3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators

摘要

3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators are provided. A compound is represented by the formula (1), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, wherein A is a nitrogen atom or CR<4>, B is an oxygen atom, a sulfur atom or NR<9> (provided that when A is a nitrogen atom, B is not NH), R<1> is a C<2-14>; aryl group, L<1> is a bond, CR<10>R<11>, an oxygen atom, a sulfur atom or NR<12>, X is OR<13>, SR<13> or NR<14>NR<15>, R<2> is a hydrogen atom, a formyl group, a C<1-10>; alkyl group or the like, L<2> is a bond or the like, L<3> is a bond, CR<17>R<18>, an oxygen atom, a sulfur atom or NR<19>, L<4> is a bond, CR<20>R<21>, an oxygen atom, a sulfur atom or NR<22>, Y is an oxygen atom, a sulfur atom or NR<23>, and R<3> is a C<2-14>.