Selective synthesis of CF3-substituted pyrimidines

摘要

The present invention relates to a method of making a compound of the formula wherein X¹, X² and R³-R⁴ are as defined herein. The method includes reacting a compound of the formula with an amine of formula 3 (HNR³R⁴) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.