| 摘要 |
<p>The present invention relates to a method of producing a mixture of 5±-pregnane derivatives represented by the formula (II) and the formula (III), which is characterized by reacting a pregnane derivative represented by the formula (I) with a metal selected from alkali metals and alkaline earth metals in the presence of a proton donor and an amine and/or ammonia. According to the present invention, a method capable of producing 5±-pregnane derivatives useful as synthetic intermediates for squalamine, in a high yield from easily available raw materials, can be provided:
wherein R 1 is a hydroxyl-protecting group, and R 2 , R 11 and R 12 are each independently a hydrogen atom or a hydroxyl-protecting group.</p> |
