| 发明名称 |
SELECTIVE CRYSTALLIZATION OF 3-PYRIDYL-1-HYDROXYETHYLIDENE-1,1-BISPHOSPHONIC ACID SODIUM AS THE HEMIPENTAHYDRATE OR MONOHYDRATE |
| 摘要 |
The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1- bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or bo th of the hydrate forms
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| 申请公布号 |
CA2399976(C) |
申请公布日期 |
2007.03.27 |
| 申请号 |
CA20012399976 |
申请日期 |
2001.02.01 |
| 申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
CAZER, FREDERICK DANA;REDMAN-FUREY, NANCY LEE;BILLINGS, DENNIS MICHAEL;PARRY, GREGORY EUGENE |
| 分类号 |
A61K31/663;C07F9/58;A61K31/675;A61P3/14;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P25/00;A61P29/00 |
主分类号 |
A61K31/663 |
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