发明名称 |
ANTIBODIES WITH SPECIFICITY FOR MULTIPLE ADHESION MOLECULES |
摘要 |
The present invention involves monoclonal antibodies which recognize a commo n determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selecti n (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis; treatment and prevention of diseases associated with inflammation. The monoclonal antibodi es are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described .
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申请公布号 |
CA2134966(C) |
申请公布日期 |
2007.03.27 |
申请号 |
CA19932134966 |
申请日期 |
1993.05.21 |
申请人 |
RESEARCH AND DEVELOPMENT INSTITUTE, INC. |
发明人 |
JUTILA, MARK A. |
分类号 |
C12P21/08;G01N33/53;A61K38/00;A61K39/395;A61P9/00;A61P9/10;A61P11/00;A61P29/00;A61P37/00;C07K16/28;C12N5/10;C12N5/18;C12N5/20;C12N15/02;C12R1/91;G01N33/564;G01N33/577 |
主分类号 |
C12P21/08 |
代理机构 |
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主权项 |
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