发明名称 |
COMPOSITIONS AND METHODS RELATING TO PYRIMIDINE SYNTHESIS INHIBITORS. |
摘要 |
<p>Provided herein are compositions comprising a pyrimidine synthesis inhibitor and a pharmaceutically acceptable carrier. Such compositions can be used in methods of increasing Na+ dependent fluid clearance by a pulmonary epithelial cell; of treating a pulmonary disease in a subject; of reducing one or more symptoms or physical signs of a respiratory syncytial virus infection in a subject; of identifying a subject at risk for respiratory syncytial virus infection and administering to the subject a composition comprising an effective amount of a pyrimidine synthesis inhibitor; of identifying a subject with a respiratory syncytial virus infection and administering to the subject a composition comprising a pyrimidine synthesis inhibitor in an amount effective to reduce Na+ dependent alveolar fluid in the subject; and of screening for a test compound that increases Na+ dependent fluid uptake by a pulmonary epithelial cell.</p> |
申请公布号 |
MXPA06013435(A) |
申请公布日期 |
2007.03.23 |
申请号 |
MX2006PA13435 |
申请日期 |
2005.05.20 |
申请人 |
THE UAB RESEARCH FOUNDATION. |
发明人 |
SADIS MATALON;IAN C. DAVIS |
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